succinate dehydrogenase b subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum琥珀酸脱氢酶b亚基免疫组织化学表达预测回肠的攻击性在高度分化的神经内分泌肿瘤.pdf

Cancers 2012, 4, 808-820; doi:10.3390/cancers4030808 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Succinate Dehydrogenase B Subunit Immunohistochemical Expression Predicts Aggressiveness in Well Differentiated Neuroendocrine Tumors of the Ileum 1 2 3 1 4 Massimo Milione , Sara Pusceddu , Patrizia Gasparini , Flavia Melotti , Patrick Maisonneuve , Vincenzo Mazzaferro 5, Filippo G. de Braud 2 and Giuseppe Pelosi 1,6,* 1 Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I-20133, Italy 2 Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I-20133, Italy 3 Molecular Cytogenetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I-20133, Italy 4 Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan 20141, Italy 5 Division of Gastrointestinal Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I-20133, Italy 6 Department of Medicine, Surgery and Dentistry, Università degli Studi, Facoltà di Medicina, Milan 20122, Italy * Author to whom correspondence should be addressed; E-Mail: giuseppe.pelosi@unimi.it; Tel.: +39-02-2390-2260; Fax: + 39-02-2390-2877. Received: 18 July 2012; in revised form: 6 August 2012 / Accepted: 9 August 2012 / Published: 16 August 2012 Abstract: Immunohistochemical loss of the succinate dehydrogenase subunit B (SDHB) has recently been reported as a sur