somatic comorbidity in anorexia nervosa first results of a 21-year follow-up study on female inpatients躯体合并症在神经性厌食症的21年随访研究结果在女性住院病人.pdf

Erdur et al. BioPsychoSocial Medicine 2012, 6:4 /content/6/1/4 RESEARCH Open Access Somatic comorbidity in anorexia nervosa: First results of a 21-year follow-up study on female inpatients 1* 1 2 1 1 Laurence Erdur , Bettina Kallenbach-Dermutz , Vicky Lehmann , Frank Zimmermann-Viehoff , Werner Köpp , Cora Weber1 and Hans-Christian Deter1 Abstract Background: Anorexia nervosa is a severe psychosomatic disease with somatic complications in the long-term course and a high mortality rate. Somatic comorbidities independent of anorexia nervosa have rarely been studied, but pose a challenge to clinical practitioners. We investigated somatic comorbidities in an inpatient cohort and compared somatically ill anorexic patients and patients without a somatic comorbidity. In order to evaluate the impact of somatic comorbidity for the long-term course of anorexia nervosa, we monitored survival in a long-term follow-up. Method: One hundred and sixty-nine female inpatients with anorexia nervosa were treated at the Charité University Medical Centre, Campus Benjamin Franklin, Berlin, between 1979 and 2011. We conducted retrospective analyses using patient’s medical and psychological records. Information on survival and mortality were required through the local registration office and was available for one hundred patients. The mean follow-up interval for this subgroup was m = 20.9 years (sd = 4.7, min = 13.3, max = 31.6, range = 18.3). We conducted survival analysis using cox regression and included somatic comorbidity in a multivariate model. Results: N = 41 patients (24.3%) showed a somatic comorbidity, n = 13 patients (7.7%) showed somatic comorbidities related to anorexia nervosa and n = 2