comparative studies of vertebrate platelet glycoprotein 4 (cd36)比较研究脊椎动物血小板糖蛋白4(cd36).pdf

Biomolecules 2012, 2, 389-414; doi:10.3390/biom2030389 OPEN ACCESS biomolecules ISSN 2218-273X /journal/biomolecules/ Review Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36) Roger S. Holmes Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia; E-Mail: r.holmes@.au; Tel.: +61-7-3735-7773 Received: 2 August 2012; in revised form: 6 September 2012 / Accepted: 18 September 2012 / Published: 24 September 2012 Abstract: Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes. CD36 also influences various diseases, including angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia and obesity. Genetic deficiency of this protein results in significant changes in fatty acid and oxidized lipid uptake. Comparative CD36 amino acid sequences and structures and CD36 gene locations were examined using data from several vertebrate genome projects. Vertebrate CD36 sequences shared 53– 100% identity as compared with 29–32% sequence identities with other CD36-like superfamily members,