p38MAPK信号传导通路及其抑制剂的研究现状.pdf

596 安 徽 医 药 A nhuiM edical and Pharmaceutical J ournal 2010 M ay; 14 ( 5) p38 MAPK 信号传导通路及其抑制剂的研究现状 , , ( 安徽医科大学第一附属医院器官移植中心, 安徽 合肥 230022) : ( m itogen- activa ted p o tein k inases, M APK s) , p38 M APK MA PK , , , , , p38 M APK , : ; p38; p38 m itogen activated protein kinase pathway and its inhibitor ZHANG P in-jie, ZHU L -i x in, GENG X iao-ping ( D ep artm ent of G eneral Surg ery, The F irst Aff iliated H osp ital of Ahhui M ed ical University, H ef ei 230022, China A bstrac t: The cascade eaction of m itogen-activa ted p ote in k inases( MA PK s) is one of the v ita l int ace llu la signa l t ansduction sys- tem s, p38 be ing a m em be ofM APK s. It can change the leve l of gene exp ession th ough phospho y lation of t ansc iption facto and is in- vo lv ed in int ace llu la in fo m ation t ansfe . It can espond to w ide ex t acellula stmi u lus and m ed iate g ow th, deve lopm ent, d iffe entiation and death of ce lls. The ecent esea ches ind ica te that p38 MA PK play s a m ajoy o le in the deve lopm ent ofm any d iseases and its inhib ito ach ieves encou ag ing esu lts in anmi a lm ode l of e lated d iseases and c lin ica l t ial. K ey w ord s: m itogen- activated p o tein k inases; p38; inh ibito ( m itogen- ac tivated p ote inkinases, Ex ip, M APK , M A PK s) , ( comm on docking dom a in); p38 4 MA PK , p382, p38 8 M APK : C-Jun N / ( c-Jun N- te m inal 6, p38 p38, k inases/ st ess ac tivated p o te in k inases, JNK s /SA PK s) ; p382 ; p38 ( ext ace llu la s igna l egu la ted kinases, ; p38 ERK s), ERK5 / 1( big MA P kinase 1, , p38p38 BMK 1), p38 MA PK , , 40% p38 MA PK , ( LPS), , p38 M APK