基于代谢组学头颈癌生物标志物研究进展.PDF

科技导报2014，32（21） 基于代谢组学的头颈癌生物标志物研究基于代谢组学的头颈癌生物标志物研究 进展进展 1，2 2 1 1 1，2 张小涛 ，侯宏卫 ，刘勇 ，王安 ，胡清源 1. 中国科学院合肥物质科学研究院；中国科学院安徽光学精密机械研究所，合肥 230031 2. 国家烟草质量监督检验中心，郑州450001 摘要摘要 头颈癌被列为世界上第六大癌症，头颈癌的主要诱因是人类乳头瘤病毒、酒精和烟草。由于缺乏早期检测和风险评估的 生物标记物，超过50%的头颈癌患者往往在晚期阶段才能确诊，5年期幸存率低于50%。基于代谢组学技术的高通量分析方法 具有发现肿瘤相关标志物的潜能，综述了代谢组学技术在头颈癌生物标志物发现中的应用进展和存在的问题，展望了进一步研 究的主要方向。 关键词关键词 代谢组学；头颈癌；生物标志物 中图分类号中图分类号 O657.6 文献标志码文献标志码 A doidoi 10.3981/j.issn.1000-7857.2014.21.011 BiomarkersofHeadandNeckCancersforMetabolomics 1,2 2 1 1 1,2 ZHANGXiaotao ,HOUHongwei,LIUYong,WANGAn,HUQingyuan 1.AnhuiInstituteofOpticsandFineMechanics,HefeiInstitutesofPhysicalScience,ChineseAcademyofSciences, Hefei230031,China 2.ChinaNationalTobaccoQualitySupervisionTestCentre,Zhengzhou450001,China AbstractAbstract The head and neck cancers are the sixth most common cause of cancer deaths. The head and neck squamous cell carcinomas (HNSCCs) are caused by the tobacco and alcohol consumption and by the infection of high-risk types of human papillomavirus. Due to the lack of biomarkers for early detection and risk assessment, more than 50% of head and neck cancer patientsareoftendiagnosedatalatestage,andthefive-yearsurvivorrateislowerthan 50%.Thehigh-throughputanalysismethod based on the metabolomics technology has the potential to come up with tumor-associated biomarkers. This paper reviews the progressandchallengesofthemetabolomicstechnologyinitswayintothebiomarkerdiscoveryoftheheadandneckcancer,andthe futuredevelopmentisalsodiscussed. KeywordsKeywords metabolomics；headandneckcancer;biomarkers [2] 头颈部肿瘤包括除眼、脑、耳、甲状腺和食道外源于头颈 型的头颈癌病