The ReninAngiotensin Aldosterone System ...（ReninAngiotensin醛固酮系统u2026u2026）.pdf

The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition Steven A. Atlas, MD AbStrAct he renin-angiotensin aldosterone system (RAAS) plays an BAckgRound: The renin-angiotensin aldosterone system (RAAS) is a integral role in the homeostatic control of arterial pressure, hormonal cascade that functions in the homeostatic control of arterial Ttissue perfusion, and extracellular volume. It functions pressure, tissue perfusion, and extracellular volume. dysregulation of the as an unusual endocrine axis in which the active hormone, RAAS plays an important role in the pathogenesis of cardiovascular and renal disorders. angiotensin (Ang) II, is formed in the extracellular space by sequential proteolytic cleavage of its precursors. This pathway oBjecTIveS: To review the role of the RAAS in the development of hypertensive cardiovascular disease and related conditions and provide an is initiated by the regulated secretion of renin, the rate-limiting overview of the classes of pharmacologic agents that inhibit this system. processing enzyme. Although renin was discovered more than a 1 ReSulTS : The RAAS is initiated by the regulated secretion of renin, the century ago, the significance of this system in the pathogenesis rate-limiting enzyme that catalyzes the hydrolysis of angiotensin (Ang) I of cardiovascular and r