the encoding of temporally irregular and regular visual patterns in the human brain暂时的不规则的编码和定期在人类大脑视觉模式.pdf

The Encoding of Temporally Irregular and Regular Visual Patterns in the Human Brain 1 1 1 2 Semir Zeki *, Oliver J. Hulme , Barrie Roulston , Michael Atiyah 1 Wellcome Laboratory of Neurobiology, Anatomy Department, University College London, London, United Kingdom, 2 School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom Abstract In the work reported here, we set out to study the neural systems that detect predictable temporal patterns and departures from them. We used functional magnetic resonance imaging (fMRI) to locate activity in the brains of subjects when they viewed temporally regular and irregular patterns produced by letters, numbers, colors and luminance. Activity induced by irregular sequences was located within dorsolateral prefrontal cortex, including an area that was responsive to irregular patterns regardless of the type of visual stimuli producing them. Conversely, temporally regular arrangements resulted in activity in the right frontal lobe (medial frontal gyrus), in the left orbito-frontal cortex and in the left pallidum. The results show that there is an abstractive system in the brain for detecting temporal irregularity, regardless of the source producing it. Citation: Zeki S, Hulme OJ, Roulston B, Atiyah M (2008) The Encoding of Temporally Irregular and Regular Visual Patterns in the Human Brain. PLoS ONE 3(5): e2180. doi:10.1371/journal.pone.0002180 Editor: Ernest Greene, University of Southern California, United States of America Received December 20, 2007; Accepted April 3, 2008; Published May 14, 2008 Copyright: 2008 Zeki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original a