cytokines and adhesion molecules expression in the brain in human cerebral malaria大脑的细胞因子和粘附分子表达在人类脑型疟疾.pdf

Int. J. Environ. Res. Public Health 2005, 2(1), 123–131 International Journal of Environmental Research and Public Health ISSN 1660-4601 © 2005 by MDPI Cytokines and Adhesion Molecules Expression in the Brain in Human Cerebral Malaria 1 1,2 3 1,2 1 1 Henry Armah , Edwin Kwame Wiredu *, Alfred Kofi Dodoo , Andrew Anthony Adjei , Yao Tettey , Richard Gyasi 1Department of Pathology, University of Ghana Medical School, 2Department of Medical Laboratory Sciences, School of Allied Health Sciences, and 3Histology Electron Microscopy Unit, Noguchi Memorial Institute for Medical Research, University of Ghana College of Health Sciences, Accra, Ghana. *Correspondence to Prof. Edwin Kwame Wiredu. Email: edwin_wiredu@ Received: 15 November 2004 / Accepted: 06 February 2005 / Published: 30 April 2005 Abstract: Although the role of systemic proinflammatory cytokines, IL-1β and TNF-α, and their up-regulation of adhesion molecules, ICAM-1, VCAM-1 and E-Selectin, in the pathogenesis of cerebral malaria (CM) is well established, the role of local cytokine release remain unclear. Immunohistochemistry (IHC) was used to compare the expression of ICAM-1, VCAM-1, E-Selectin, IL-1β, TNF-α and TGF- β at