临床大数据分析与挖掘3.ppt-湘雅医院.ppt

报告内容 一、生物医学大数据分析挖掘的几个方向 二、基于流感大数据发展流感预测预警新方法 报告内容 一、生物医学大数据分析挖掘的几个方向 二、基于流感大数据发展流感预测预警新方法 新方法优于目前WHO使用的方法 . Based on 7 seasons during 2002-2009. 世界卫生组织WHO：对中国地区 2/7；其他北半球地区4/7 我们预测的准确度: 对中国地区 6/7；其他北半球地区6/7。 X X X X X X X X X X 1，目前该方法已经申请了专利。 2，在使用我们的方法向WHO推荐疫苗参考株。 3，Nature Communcations, 2012. . X X X X X X X X X X 新华社发布的新闻：我国科学家发明流感疫苗株快速选择新技术 这是因为目前WHO推荐的疫苗频繁地不匹配。 Despite this global effort, vaccine recommendation still presents a significant challenge as evidenced by vaccine mismatches in the past (8-13). 2, Moreover, reports also suggest that the degree of antigenic mismatch may vary with region, and may be a particular problem in some Asian regions that are sources of new variants. By comparing WHO-recommended vaccine strains with the epidemic strains in Taiwan from 1987-1988 to 2003-2004, Hsieh et al found that the vaccine mismatch rate for influenza A (H3N2) viruses in Taiwan was 47%, higher than the 35% in Canada (8, 14). This shows the urgent need for the development of a more effective influenza surveillance program to assist WHO in global vaccine strain recommendation. Despite this global effort, vaccine recommendation still presents a significant challenge as evidenced by vaccine mismatches in the past (8-13). 2, Moreover, reports also suggest that the degree of antigenic mismatch may vary with region, and may be a particular problem in some Asian regions that are sources of new variants. By comparing WHO-recommended vaccine strains with the epidemic strains in Taiwan from 1987-1988 to 2003-2004, Hsieh et al found that the vaccine mismatch rate for influenza A (H3N2) viruses in Taiwan was 47%, higher than the 35% in Canada (8, 14). This shows the urgent need for the development of a more effective influenza surveillance program to assist WHO in global vaccine strain recommendation. DXplain系统是美国波士顿马萨诸塞州综合医院计算机科学实验室的杰作，从1986年就开始投入使用，并在1987年实现全美通行。经历了这些年的发展壮大，它的知识体系已经从最初的约500个病种扩大到现在的2400个，还有5000个临床新发现和230000个资料点。至今该系统还在美国医院中普遍使用。