Osterix：与成骨细胞分化和骨形成有关的转录因子.doc

Osterix：与成骨细胞分化和骨形成有关的转录因子 4 5 6 7 8 9 10 ? 252国外医学内分泌学分册2004年7月第24卷第4期SectionEndocrinolForeignMedSci,July2004,Vol24.No.4 anovelregulatorofosteoblastfunctions.JBiolChem,1999,274:17123一 l7l31. SafadiFF,XuJ,SmockSL,eta1.Expressionofconnectivetissuegrowth factorinbone:itsroleinosteoblastproliferationanddifferentiationin vitroandboBeformationinvivo.JCellPhysiol,2003.196:51.62. PereiraRC,DurantD,CanalisE.Transcriptionalregulationofconnective tissuegrowthfactorbycortisolinosteoblasts.AmJPhysiolEndocrinol Metab,2000,279:E570一E576. XuJ,SmockSL,SafadiFF,eta1.Cloningthefull-lengthcDNAforrat connectivetissuegrowthfactor:implicationsforskeletaldevelopment.J Cel1BiolChem,2000,77:103-l15. Goppeh-StruebeM,HahnA,1wanciwD,eta1.Regulationofconnective tissuegrowthfactor(ccn2,ctsf)geneexpressioninhumanmesangial cells:modulationbyHMGCoAreducta.seinhibitors(statins).JClin PatholMolPathol.2001.54:176-179. Par1(SK.KimJ,SeomunY,eta1.Hydrogenperoxideisanovelinducer ofconnectivetissuegrowthfactor.BiochemBiophysResCommun,2001, 284:966-971. SchildC.TroebB.Mechanicalstressisrequiredf0rhigh—levelexpres- sionofconnectivetissuegrowthfactor.ExpCellRes,2002,274:83-91. NakanishiT,NishidaT.ShimoT,eta1.EctsofCTGF/Hcs24,aprod- uctofahypertrophicchondrocyte-specificgene,ontheproliferationand differentiationofchondrocytesinculture.Endocrinology,2000.141:264— 273. 11NishidaT,KubotaS,NakanishiT,eta1.CTGF/Hcs24,ahypertrophic chondrocytespecificgeneproduct,stimulatesproliferation,anddifferen— tiation,butnothypertrophyofculturedarticularchondrocytes.JCell Physiol,2002,192:55—63. 12NakanishiT.YamaaiT.AsanoM.eta1.Overexpressionofconnectivetis. suegrowthfactor/hypertrophicchondrocyte—specificgeneproduct24de- creasesbonedensityinadultmiceandinducesdwarfism.BiochemBio— physResCommun,2001,281:678-681. 13NishidaT,KubotalS,KojimaS,eta1.Regulationofdefectsintheat-tic? ularcartilageinratkneejointsbyconnectivetissuegrowthfactor/hyper- trophicchondrocyte-specificgeneproduction24(CTGF/HCS24).JSBMR WORKSHOP1:Differentiationa