调控成骨细胞分化和骨形成关键信号通路的研究进展.PDF

1484 Chinese Journal of Reparative and Reconstructive Surgery, December 2014, Vol. 28, No.12 · · 调控成骨细胞分化及骨形成关键信号通路的研究进展调控成骨细胞分化及骨形成关键信号通路的研究进展 【 综述在成骨细胞分化及骨形成过程中起关键调节作用的相关信号通路作用机制及研究进 展。 查阅近年来与成骨细胞分化及骨形成信号通路相关的文献，并进行综合分析。 目前已发现多条信 号通路参与了成骨细胞分化及骨形成的调节，其中 BMP-Smads 、Wnt/β-catenin、Notch 、Hedgehog 、FGF 信号通路的作用最 关键。这些信号通路不但自身具有较复杂的调控机制，而且彼此相互联系、相互影响，从而组成了一个更复杂而精细的调 控网络，共同参与成骨细胞分化及骨形成的调节。然而，由于相关动物实验技术不成熟，临床试验研究较少，其详细作用 机制体系仍不十分明了。 对成骨相关信号通路的进一步深入研究，将有望彻底揭开成骨细胞分化及骨形成过程 的完整分子机制，从而为临床有效防治成骨分化及骨形成异常性疾病提供理论依据。 MSCs 成骨细胞分化 骨形成 信号通路 RESEARCH PROGRESS OF KEY SIGNALING PATHWAYS IN OSTEOBLAST DIFFERENTIATION AND BONE FORMATION REGULATION/XU Lian, KONG Qingquan. Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Corresponding author: KONG Qingquan, E-mail: kqqspine@126.com 【Abstract 】 Objective To review the mechanism and research progress of signaling pathways which play key roles in the regulation of osteoblast dif erentiation and bone formation. Methods Recent articles about signaling pathways of osteoblast dif erentiation and bone formation were reviewed and comprehensively analyzed. Results At present, multiple signaling pathways have been found to be involved in the regulation of osteoblast dif erentiation and bone formation, among which bone morphogenetic protein-Smads, Wnt/β-catenin, Notch, Hedgehog, and i broblast growth factor signaling pathways may play the most important roles. Not only each pathway has a complex regulatory mechanism itself, but also contacts and impacts with each other, thus they formed a more complicated and sophisticated regulatory network, and regulate together osteoblast dif erentiation and bone formation. However, the mechanisms in detail of those pathways are s