经典wnt信号通路在恶性淋巴瘤中的研究进展-tumor.pdf

940 　　肿瘤2012 年11 月第32 卷第11 期　TUM OR Vol. 32, November 2012 DOI: 10.3781/j .issn.1000-7431.2012 .11.015 Copyright© 2012 by TUM OR Review 综述 · 经典Wnt信号通路在恶性淋巴瘤中的研究进展 曲　琦，黄洪晖 上海交通大学医学院附属仁济医院血液科，上海200127 [摘要]　Wnt 信号通路是调控机体胚胎及器官发育的重要信号通路之一，在细胞增殖、分化、极化、黏附和运动 等生理过程中发挥重要作用；许多肿瘤的发病涉及经典Wnt 通路的异常持续性激活。近年来，在恶性淋巴瘤发病 研究中有许多涉及Wnt 信号通路的激活。本文就经典Wnt 信号通路在淋巴细胞发育和恶性淋巴瘤发病中的研究 进展进行简要综述，旨在进一步探索淋巴瘤的发病机制，揭示基于该通路的潜在靶向治疗的可能。 [关键词]　淋巴瘤；Wnt 蛋白质类；Wnt 信号通路 [中图分类号]　R733.41 [文献标志码] A [文章编号]　1000-7431 (2012) 11-0940-05 Advances in research on canonical Wnt signaling pathways in malignant lymphomas QU Qi, HUANG Hong-hui Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China [A BST RA CT]　Wnt signaling pathway is an important pathway for regulating the development of embryo and organs. It has been shown to play a key role in proliferation, differentiation, polarity, adhesion and motility of cells. The constitutive activation of canonical Wnt pathway is involved in the pathogenesis of many carcinomas. In recent years, accumulating studies have suggested its association with the pathogenesis of malignant lymphomas. This review summarizes the latest progress in research on canonical Wnt pathway and its role in lymphocyte development and the occurrence of malignant lymphomas, in order to provide the new clues of mechanism for pathogenesis of lymphomas and then disclose new potential therapeutic targets which are based on this pathway. [KEY WORDS]　Lymphoma; Wnt proteins; Wnt signaling pathways TUMOR , 2012, 32 (11): 940-944] [ 追溯Wnt