systematic study of the physicochemical properties of a homologous series of aminobisphosphonates物化特性的系统研究aminobisphosphonates同源系列.pdf

Molecules 2012, 17, 10928-10945; doi:10.3390/molecules170910928 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates 1 2 3 1 1 Aino-Liisa Alanne , Helena Hyvönen , Manu Lahtinen , Markku Ylisirniö , Petri Turhanen , Erkki Kolehmainen 3, Sirpa Peräniemi 1 and Jouko Vepsäläinen 1,* 1 School of Pharmacy, University of Eastern Finland, Biocenter Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland 2 Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 Helsinki, Finland 3 Department of Chemistry, University of Jyväskylä, P.O. Box 35, FIN-40014 Jyväskylä, Finland * Author to whom correspondence should be addressed; E-Mail: jouko.vepsalainen@uef.fi; Tel.: +358-403-553-256. Received: 7 August 2012; in revised form: 4 September 2012 / Accepted: 5 September 2012 / Published: 12 September 2012 Abstract: Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H N(CH ) C(OH)[P(O)(OH) ] ,