substituted n-benzylpyrazine-2-carboxamides synthesis and biological evaluation代替n-benzylpyrazine-2-carboxamides合成和生物学评价.pdf

Molecules 2012, 17, 13183-13198; doi:10.3390/molecules171113183 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Substituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation † Barbora Servusová 1,*, Drahomíra Eibinová 1, Martin Doležal 1, Vladimír Kubíček 2, Pavla Paterová 3, Matúš Peško 4 and Katarína Kráľová 5 1 Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic; E-Mails: eibid5aa@faf.cuni.cz (D.E.); dolezalm@faf.cuni.cz (M.D.) 2 Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic; E-Mail: kubicek@faf.cuni.cz 3 Department of Clinical Microbiology, University Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic; E-Mail: pavla.paterova@fnhk.cz 4 Department of Ecosozology and Physiotactics, Faculty of Natural Sciences, Comenius University, Mlynská Dolina Ch-2, 84215 Bratislava, Slovakia; E-Mail: matus.pesko@ 5 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská Dolina CH-2, 842 15 Bratislava, Slovakia; E-Mail: kralova@fns.uniba.sk † Preliminary results related to the topic of this article were presented at The Fifteenth International Electronic Conference on Synthetic Organic Chemistry (ECSOC-15, / viewer?url=/presentation/599/pdfchrome=true), 1–30 November 2011. * Author to whom correspondence should be addressed; E-Mail: barbora.servusova@faf.cuni.cz; Tel.: +420-495-067-272; Fax