solitary fibrous tumors of the soft tissues imaging features with histopathologic correlations孤独的纤维肿瘤的软组织成像特征与病理的相关性.pdf

Papathanassiou et al. Clinical Sarcoma Research 2013, 3:1 /content/3/1/1 CLINICAL SARCOMA RESEARCH RESEARCH Open Access Solitary fibrous tumors of the soft tissues: imaging features with histopathologic correlations Zafaria G Papathanassiou, Marco Alberghini, Piero Picci, Eric Staals, Marco Gambarotti, * Francesco Giuseppe Garaci and Daniel Vanel Abstract Purpose: To describe the imaging features of soft tissue solitary fibrous tumors, with histopathological correlations and clinical outcome. Material and methods: Twenty-seven patients with histologically proven SFTs were retrospectively evaluated. Imaging studies included six radiographs, five U/S studies, eighteen CT scans, fourteen MRI exams, and one angiography. Results: On CT scans, two lesions were isodense and five were mildly hypodense compared to muscle while 11 lesions appeared heterogeneous-mixed of iso and hypodense areas. Heterogeneous enhancement was depicted in 13 lesions and four lesions enhanced homogeneously. Six lesions were partially calcified. On T1W MR images, seven lesions were isointense and one was slightly hyperintense relative to adjacent muscles while five lesions appeared heterogeneous-mixed of iso and hypointense areas. T2W images showed high SI in two cases and heterogeneous- mixed in seven cases. Enhancement was heterogeneous in six and homogeneous in four lesions. Patchy unenhanced areas (on CT and T1W MR images) along with patchy areas of low to markedly high SI on T2W images were depicted in 19 lesions. The enhanced portions correlated to areas of increased vascularity and cellularity. The four clinically more aggressive lesions could not be predicted on imaging. Conclusion: Typical soft tissue SFTs are deep masses ma