分子印迹技术在天然产物分离纯化中的应用.pdf

第42 卷第8 期 东 北 农 业 大 学 学 报 42(8): 146~153 2011 年8 月 Journal of Northeast Agricultural University August 2011 分子印迹技术在天然产物分离纯化中的应用 1, 2 1 1 1 1 1 2 2 杨 鑫 ，张 华，董爱军，张英春，赵海田，姚 磊，佘永新，王 静 （1. 哈尔滨工业大学食品科学与工程学院，哈尔滨 150090；2. 中国农业科学院，北京 100081） 摘 要：天然产物体系复杂，且有效成分含量低，采用一般的分离方法富集难度较大。分子印迹技术是制备 高选择性分离介质的有效技术手段，分子印迹聚合物(MIPs)的选择性强，分离操作简单，在各种分离纯化中展现 了良好的应用前景。文章综述了目前分子印迹技术在天然产物的分离纯化中的研究进展。 关键词：分子印迹技术；有效成分；分离；纯化；天然产物 中图分类号：O636 文献标志码：A 文章编号：1005-9369 （2011）08－0146－08 Application of molecular imprinting technology in separation and puri- 1,2 1 fication of active ingredients from natural products/YANG Xin , ZHANG Hua , 1 1 1 1 2 2 DONG Aijun , ZHANG Yingchun , ZHAO Haitian , YAO Lei , SHE Yongxin , WANG Jing (1. School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; 2. Chinese Acedemy of Agricutureal Sciences, Beijing 100081, China) Abstract: Active ingredients of natural products are in low content and difficult to be enriched by general methods. Molecular imprinting technology (MIT) is promising in preparing highly selective separation matrixes. Molecularly-imprinted polymers (MIPs) show good prospect in the purification of active ingredients from natural products. In this review, the application of molecular imprinting technology in the separation and purification of active ingredients was introduced. Key words: molecular imprinting technology; active ingredient; separation; purification; naturalproduct