蛋白质组学及其在糖尿病肾病中的应用.pdf

2004 11 24 6 Urology a d ephrology FMS, Nov 2004, Vol. 24 NO. 6 829 蛋白质组学及其在糖尿病肾病中的应用 X 苏克亮 综述 黄松敏 审校 = , = ; [ ] R692. 39 [ ] A [ ] 1001-4594( 2004) 06-0829-04 ( DM) : ¹ , 40% ; º ACEI ARB ; »mRNA ; , ¼mRNA ; ½ ( DN) , , 2% , , 98% [ 4] ( proteomics) , , , DN [ 5] 1 , 1994 , Wilki s Williams [ 1] , , ( proteome) , , ( EST) , [2] , , , [3] , , associated e d- stage re al disease.Kid ey I t, 2003, 63: 1051- 1057. pati bility leukocyte a tige - matched do or bo e marrow a d re al 20 Zeier M, Perz J, Li ke RP, et al. No regressio of re al AL amyloid i tra spla tatio for multiple myeloma with e d stage re al disease: the i- mo oclo al gammopathy after successful autologousblood stem cell tra s- ductio of allograft tolera ce through mixed lymphohematopoietic pla tatio a d sig ifica t cli ical improveme t. Nephrol Dial Tra spla t, chimerism.Tra spla tatio , 1999,68( 4) : 480- 484. 2003, 18: 2644- 2647. ( : 2004-05- 11) 21 Spitzer TR, Delmo ico F,Tolkoff- Rubi N, et al. Combi ed histocom- X :610041 , 830 2004 1124 6 Urology a d eph