小剂量氨氯地平联合缬沙坦用于老年原发高血压合并糖尿病治疗效果评价.docx
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小剂量氨氯地平联合缬沙坦用于老年原发高血压合并糖尿病治疗效果评价
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摘要:目的探究小剂量氨氯地平联合缬沙坦用于老年原发高血压合并糖尿病治疗效果。方法随机选取2015年2月~2016年12月在我院进行治疗的130例老年原发高血压合并糖尿病患者,根据治疗方法的不同随机分为治疗组(氨氯地平配合缬沙坦使用)和对照组(只使用缬沙坦),分析治疗后两组患者的血压血糖及不良反应发生情况。结果治疗组患者的的血压控制情况明显好于对照组(P0.05),治疗组患者的餐前血糖和餐后2h血糖值都明显低于对照组(P0.05),治疗组的血压控制总效率为97.1%,明显大于对照组的81.6%(P0.05),治疗组的不良反应发生率为5.7%明显小于对照组的16.6%(P0.05)。结论使用小剂量氨氯地平配合缬沙坦治疗老年原发高血压合并糖尿病患者,效果明显,安全性高,值得在临床上推广使用。
关键词:氨氯地平;缬沙坦;高血压合并糖尿病
Evaluationoflowdoseamlodipinecombinedwithvalsartaninthetreatmentofelderlypatientswithprimaryhypertensioncomplicatedwithdiabetesmellitus
WuLibei
TheFourthPeoplesHospitalofPingjiangCounty,HunanPingjiang414500
[Abstract]Objective:Toinvestigatetheefficacyoflow-doseamlodipinecombinedwithvalsartaninthetreatmentofelderlypatientswithprimaryhypertensioncomplicatedwithdiabetesmellitus.Methods:randomlyselectedinFebruary2015December~2016of130elderlypatientstreatedinourhospitalinpatientswithprimaryhypertensionanddiabetes,accordingtothedifferenttreatmentmethodswererandomlypidedintotreatmentgroup(amlodipinecombinedwithvalsartanused)andcontrolgroup(onlyusingvalsartan),analysisandtheincidenceofadversereactionoftwogroupsofpatientswithbloodpressureandbloodsugartreatmentaftertreatment.Results:thetreatmentgroupofpatientswithbloodpressurecontrolwassignificantlybetterthanthecontrolgroup(P0.05),patientsinthetreatmentgroup,fastingbloodglucoseandpostprandial2Hbloodglucosevaluesweresignificantlylowerthanthecontrolgroup(P0.05),thetreatmentgroupbloodpressurecontrolratewas97.1%,significantlyhigherthanthecontrolgroup81.6%(P0.05),adversereactionsintreatmenttheincidencerateof5.7%wassignificantlylessthanthecontrolgroup16.6%(P0.05).Conclusion:lowdoseamlodipinecombinedwithvalsartaniseffectiveandsafeinthetreatmentofelderlypatientswithprimaryhypertensioncombinedwithdiabetesmellitus.Itisworthpopularizinginclinicalpractice.
[Keywords]Amlodipine;valsartan;hypertensionassociatedwithdiabetesmellitus
糖尿病和高血压临床上常发生于老年人群中,严重影响患者的生活质量和健康[1]。高血压合并糖尿病严重者可能出现视网膜病变、肾脏病变及心脑血管疾病等。缬沙坦为血管紧张素Ⅱ受体拮抗剂,氨氯地平为钙离子拮抗剂,两者在