细胞胆固醇的生理功能及其代谢异常相关疾病的研究进展.pdf

网络出版时间：2017-10-13 16:11:15 网络出版地址：/kcms/detail/31.2035.Q1611.002.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(12): DOI: 10.11844/cj cb.2017.12.0110 细胞胆固醇的生理功能及其代谢异常 相关疾病的研究进展 1 1 2 2 1* 杨宝瑜 高天琦 李 洋 高 兵 芦秀丽 1 2 ( 辽宁大学生命科学院, 沈阳110036; 沈阳医学院基础医学院, 沈阳110034) 摘要 胆固醇是维持细胞生存及发挥多种细胞功能所必需的脂质小分子, 在细胞中受精密 的调控以保持稳态。胆固醇的稳态失衡则会引起许多疾病。该文重点介绍了胆固醇在不同方面的 生理作用, 并系统总结了几种胆固醇代谢异常相关疾病的基本情况和研究现状, 为全面了解胆固醇 代谢相关疾病提供了重要参考。 关键词 胆固醇生理功能; 动脉粥样硬化; 阿尔兹海默症; 链甾醇血症; 抑郁症 Progress in the Physiological Functions of Celluler Cholesterol and the Diseases Related to Its Metabolism Abnormalities 1 1 2 2 1* Yang Baoyu , Gao Tianqi , Li Yang , Gao Bing , Lu Xiuli 1 ( School of Life Science, Liaoning University, Shenyang 110036, China; 2School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China) Abstract Cholesterol is a small lipid molecule, and necessary for maintaining cell survival and many kinds of cellular functions. It is precisely regulated in the cell to keep its steady state. The imbalance of cholesterol content in cells may cause many kinds of diseases. In the present review we summarized the physiological roles of cholesterol in different aspects and several cholesterol abnormal