damaged dna binding protein 2 in reactive oxygen species (ros) regulation and premature senescence受损的dna结合蛋白2在活性氧(ros)监管和过早衰老.pdf

Int. J. Mol. Sci. 2012, 13, 11012-11026; doi:10.3390/ijms130911012 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Damaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence Nilotpal Roy 1, Srilata Bagchi 2 and Pradip Raychaudhuri 1,* 1 Department of Biochemistry and Molecular Genetics (M/C 669), University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA; E-Mail: nroy4@ 2 Center of Molecular Biology of Oral Diseases (M/C 860), College of Dentistry, Cancer Center, University of Illinois at Chicago, 801 S. Paulina Ave, Chicago, IL 60612, USA; E-Mail: sbagchi@ * Author to whom correspondence should be addressed; E-Mail: pradip@; Tel.: +1-312-413-0255; Fax: +1-312-355-3847. Received: 6 August 2012; in revised form: 22 August 2012 / Accepted: 28 August 2012 / Published: 5 September 2012 Abstract: Premature senescence induced by DNA damage or oncogene is a critical mechanism of tumor suppression. Reactive oxygen species (ROS) have been implicated in the induction of premature senescence response. Several pathological disorders such as cancer, aging and age related neurological abnormalities have been linked to ROS deregulation. Here, we discuss how Damaged DNA binding Protein-2 (DDB2), a nucleotide excision repair protein, plays an important role in ROS regulation