金钱草中黄酮苷的分离与结构鉴定.pdf

( ) ·196 · 药学学报 Acta Pharmaceutica Sinica 2003 ,38 3 :196 - 198 金钱草中黄酮苷的分离与结构鉴定 崔东滨 , 王淑琴 , 严铭铭 (吉林省中医中药研究院 , 吉林 长春 130021) 摘要 : 目的 　从金钱草中分离制备标准品。方法 　用硅胶柱色谱进行分离 , 通过理化方法及 IR ,UV ,MS , 1 HNMR ,13 CNMR ,DEPT ,HMQC ,HMBC 等光谱分析确定化合物结构 。结果 　从金钱草中分离得到 2 个化合物 ,分别鉴 γ ( ) α ( ) β ( ) 定为鼠李酮酸 内酯 I 、山奈酚3 O L鼠李糖 1 →2 D木糖苷 II 。结论 　II 为新化合物 ,命名为金钱草素 , I 为首次从该属植物中分离得到 。 γ 关键词 : 金钱草 ; 金钱草素 ; 黄酮苷 ; 鼠李酮酸 内酯 ( ) 中图分类号 : R284 . 1 ; R284 . 2 　　　文献标识码 : A 　　　文章编号 : 0513 - 4870 2003 03 - 0196 - 03 Isolation and structure identification of flavonol glycoside from Lysimachia christinae Hance . CUI Dongbin , WAN G Shuqin , YAN Mingming (Academy of Traditional Chinese Medicine and M ateria Medica of J ilin Province , Changchun 130021 , China) Abstract : Aim 　To isolate and prepare chemical standards. Methods 　Flavonol glycoside and rhamnonic γ acid lactone were isolated from whole plants of Lysimachia christinae Hance . with 95 % ethanol and purified 1 13 by silica gel column chromatography . UV , IR , MS , HNMR , CNMR , DEPT , HMQC , HMBC were used for the structural identification . Results 　Two compounds were obtained . They were identified as rhamnonic acid γ ( ) α ( ) β ( ) lactone I and kaempferol3O L rhamnosyl 1 →2 Dxyloside II . Conclusion 　Compound I w