细胞信号转导Signal-4-2017.ppt

1.7 NF-?B signaling pathway 2. Intracellular receptor-mediated pathways Key points for whole chapter Four key points 1. Signal molecules and the classification 2. Receptors and the classification 3. Structure and function of G protein 4. The major signaling pathways One viewpoint Signal transduction pathway is a complicated network Questions: 1. Classification and characteristics of signaling molecules. 2. Classification and characteristics of membrane and intracellular receptors. 3. Please describe the cycle of heterotrimeric G protein 4. How are about the binding properties of ligand and receptor? 5. Please briefly describe the process of the major signaling pathways 6. How is about the relationship between signal transduction and disease? Homework Terms: 1. Signaling molecules 2. First messenger 3. Secondary messenger 4. Third messenger 5. Receptor 6. G protein 7. Small G protein 8. Intracellular receptor 9. PKA 10. TPK 11. PKC 12. MAPK 13. STAT 14. NF-kB 15. TGF-β 16. IP3 17. DAG 18. CaM Next time: Chapter 21 DNA重组及重组DNA技术 DNA Recombination and Recombinant DNA Technology Thanks! See you next time! * * * * * * 1. Cross Talk of Signaling pathways （信号转导通路的交叉联系） 1. 2 Two different signaling pathways can affect on a same target protein or a same cis-acting element of DNA (两条不同的信息途径可共同作用于同一种靶蛋白或同一基因调控区) Glycogen phosphorylase kinase b (糖原磷酸化酶激酶b) is a multisubunit protein (αβγδ)4，and the δ subunit is CaM. PKA can activate the enzyme by phosphorylating α and β subunits; Ca2+ can activate the enzyme by binding to the δ subunit (CaM). Example Two different signaling pathways can affect on a same target protein phosphorylase kinaseｂ phosphorylase kinaseａ ATP phosphorylaseｂ Phosphorylase a ATP PPi Phosphoprotein phosphatase Phosphoprotein phosphatase H2O PPi ? ? ? PKA InhibitorＩa InhibitorＩb ATP Phosphoprotein phosphatase PPi Glucago