study protocol - accurate assessment of kidney function in indigenous australians aims and methods of the egfr study研究方案,准确评估肾功能的土著澳大利亚人表皮生长因子受体的研究目的和方法.pdf

Maple-Brown et al. BMC Public Health 2010, 10:80 /1471-2458/10/80 STUDY PROTOCOL Open Access Study Protocol - Accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR Study 1,2* 2 1 1 3 Louise J Maple-Brown , Paul D Lawton , Jaquelyne T Hughes , Suresh K Sharma , Graham RD Jones , Andrew G Ellis4 5 6 7 8 9 , Wendy Hoy , Alan Cass , Richard J MacIsaac , Ashim K Sinha , Mark AB Thomas , 10 11 1 7 12 9 Leonard S Piers , Leigh C Ward , Katrina Drabsch , Sianna Panagiotopoulos , Robyn McDermott , Kevin Warr , Sajiv Cherian13 14 7 12 , Alex Brown , George Jerums , Kerin O’Dea Abstract Background: There is an overwhelming burden of cardiovascular disease, type 2 diabetes and chronic kidney disease among Indigenous Australians. In this high risk population, it is vital that we are able to measure accurately kidney function. Glomerular filtration rate is the best overall marker of kidney function. However, differences in body build and body composition between Indigenous and non-Indigenous Australians suggest that creatinine- based estimates of glomerular filtration rate derived for European populations may not be appropriate for Indigenous Australians. The burden of kidney disease is borne disproportionately by Indigenous Australians in central and northern Australia, and there is significant heterogeneity in body build and composition within