terpenoids from endophytic fungi萜类化合物的内生真菌.pdf

Molecules 2011, 16, 10604-10618; doi:10.3390/molecules161210604 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Terpenoids from Endophytic Fungi Jucimar Jorgeane de Souza 1, Ivo José Curcino Vieira 1,*, Edson Rodrigues-Filho 2 3 and Raimundo Braz-Filho 1 Laboratory of Chemical Science, State University of North Fluminense Darcy Ribeiro, 28013-602, Campos dos Goytacazes, RJ, Brazil 2 Laboratory of Biochemistry of Microorganisms Micromolecules (LaBioMMi), Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil 3 Visiting Researcher — Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro / State University of North Fluminense Darcy Ribeiro / Federal Rural Universty of Rio de Janeiro, Rio de Janeiro, RJ, Brazil * Author to whom correspondence should be addressed; E-Mail: curcino@uenf.br; Tel.: +55-22-2739-7234; Fax: +55-22-2739-7248. Received: 13 November 2011; in revised form: 2 December 2011 / Accepted: 12 December 2011 / Published: 19 December 2011 Abstract: This work reviews the production of terpenoids by endophytic fungi and their biological activities, in period of 2006 to 2010. Sixty five sesquiterpenes, 45 diterpenes, five meroterpenes and 12 other terpenes, amounting to 127 terpenoids were isolated from endophytic fungi. Keywords: endophytic fungus; terpenoids; antimicrobial activity 1. Introduction Endophytic microorganisms are bacteria or fungi that live inside plant tissues at any moment of their life cycle, without causin