synthesis, structural studies and antitumoral evaluation of c-6 alkyl and alkenyl side chain pyrimidine derivatives s合成、结构研究和antitumoral评价其他烷基、烯基侧链嘧啶衍生品.pdf

Molecules 2009, 14, 4866-4879; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Structural Studies and Antitumoral Evaluation of C-6 Alkyl and Alkenyl Side Chain Pyrimidine Derivatives 1 1 2 2 Svjetlana Krištafor , Tatjana Gazivoda Kraljević , Damjan Makuc , Janez Plavec , 3 3 1, Lidija Šuman , Marijeta Kralj and Silvana Raić-Malić * 1 Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, P.O. Box 177, HR-10000 Zagreb, Croatia; E-Mails: prekupec@fkit.hr (S.K.); tgazivod@fkit.hr (T.G.K.) 2 Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, P.O. Box 660, SI-1001 Ljubljana, Slovenia; E-Mails: damjan.makuc@ki.si (D.M.); janez.plavec@ki.si (J.P.) 3 Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, P.O. Box 1016, HR- 10001, Zagreb, Croatia; E-Mails: lidija.suman@irb.hr (L.S.); marijeta.kralj@irb.hr (M.K.) * Author to whom correspondence should be addressed; E-Mail: silvana.raic@fkit.hr; Tel.: +38 51 4597 213; Fax: +38 51 4597 224. Received: 30 September 2009; in revised form: 19 November 2009 / Accepted: 25 November 2009 / Published: 27 November 2009 Abstract: The synthetic route for introduction of fluorophenylalkyl (compounds 5, 7, 14 and 15) and fluorophenylalkenyl (compounds 4E and 1