automated querying of genome databases基因组数据库的自动查询.pdf

Education Automated Querying of Genome Databases Peter Schattner (GenBank), the Expressed Sequence Tag Database (dbEST), etc. [3]—each with its own idiosyncrasies and learning curves. In contrast, using one of the genome browsers, all we need to do is to select the appropriate genome and genomic location, select the browser annotation tracks for SNPs, ESTs, repeats, CpG islands, and interspecies conservation, and view the results. However, for all its power and convenience, interactive querying of genome databases does have limitations. For example, we can imagine a situation where we have identified Introduction one hundred polymorphisms rather than just a single one. The number of molecular biology databases continues to Interactively verifying which ones are already in dbSNP, or explode. Presently, few problems in genomic molecular are within CpG islands, or are represented by ESTs, or are at biology can be addressed without analyzing data stored in highly conserved sites would quickly become tedious, time- them. However, these databas