antibodies to henipavirus or henipa-like viruses in domestic pigs in ghana, west africa猪在国内抗体存在亨德拉尼帕病毒或便是henipa-like病毒在加纳,非洲西部.pdf

Antibodies to Henipavirus or Henipa-Like Viruses in Domestic Pigs in Ghana, West Africa 1,2,3,4 5 5 1,2 6 David T. S. Hayman *, Lin-Fa Wang , Jennifer Barr , Kate S. Baker , Richard Suu-Ire , Christopher C. 7 2 1 Broder , Andrew A. Cunningham , James L. N. Wood 1 Cambridge Infectious Diseases Consortium, University of Cambridge, Cambridge, United Kingdom, 2 Institute of Zoology, Zoological Society of London, London, United Kingdom, 3 Animal Health and Veterinary Laboratories Agency, Weybridge, United Kingdom, 4 Colorado State University, Fort Collins, Colorado, United States of America, 5 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia, 6 Wildlife Division of the Ghana Forestry Commission, Accra, Ghana, 7 Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America Abstract Henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), have Pteropid bats as their known natural reservoirs. Antibodies against henipaviruses have been found in Eidolon helvum, an old world fruit bat species, and henipavirus-like nucleic acid has been detected in faecal samples from E. helvum in Ghana. The initial outbreak of NiV in Malaysia led to over 265 human encephalitis cases, including 105 deaths, with infected pigs acting as amplifier hosts for NiV during the outbreak. We detected non-neutralizing antibodies against viruses of the genus Henipavirus in approximately 5% of pig sera (N = 97) tested in Ghana, but not in a small sample of other domestic species sampled under a E. helvum roost. Although we did not detect neutralizing antibody, our results suggest p