心力衰竭与心室重构精选.ppt

* * Editorial Comment （述评） -by Tang WHW, Huang Y It is conceivable that in the future if qili qiangxin proves to provide morbidity and mortality benefits in rigorous clinical trials, it will fundamentally challenge the existing foundation of scientific inquiry based upon the precise understanding of pharmacodynamics of drug therapies. 可以想象的是，如果芪苈强心胶囊在未来高质量的临床研究中提供更多关于其对受试者发病率、死亡率益处的证据，那么它将从根本上挑战现有的关于药物效应动力学研究的科学观念。 Tang WH, Huang Y. Cardiotonic Modulation in Heart Failure: Insights from Traditional Chinese Medicine. J Am Coll Cardiol. 2013;62(12):1073-1074. Editorial Comment （述评） -by Tang WHW, Huang Y Yet even at present, the promising results reported by Li and colleagues may have already opened the opportunity to explore with the latest technologies how synergistic interactions among active TCM ingredients can benefit the syndrome of heart failure. This is a challenge that we should all warmly embrace. 现如今，这项富有前景的研究表明李及他的研究同事们已经打开了一扇如何利用最新科技研究传统中药活性成分在心力衰竭治疗中协同作用的大门。这是一个挑战，对此我们应该热烈拥抱。 Tang WH, Huang Y. Cardiotonic Modulation in Heart Failure: Insights from Traditional Chinese Medicine. J Am Coll Cardiol. 2013;62(12):1073-1074. 临床研究证据级别：由高到低 1. 随机对照研究 2. 前瞻性非随机对照研究 3. 回顾性对照研究 4. 非对照研究或历史对照研究 5. 荟萃分析 6. 病例报道 7. 评论，教授或其他专家意见 Professor Joseph S. Alpert Editor-in-Chief, American Journal of Medicine 2013.7.19 Nanjing 中国心力衰竭诊断和治疗指南2014 （中华心血管病杂志 2014(42):2） 对芪苈强心临床试验结果进行了描述（参考文献58） day MI Sacrifice 0 7 14 21 QL 21 d Working model : AMI remodeling Our work:（我们的研究） Project1: Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice Unpublished data Saline + sham Saline + MI QL + MI QL + Sham Results Unpublished data Remote Remote Remote Remote Border Infarct Border Infarct Border Border Saline + MI QL+ MI Saline + MI QL + MI Unpublished data Saline+Sham Saline+MI QL+MI PPARg1 PGC1a GAPDH PPARa Unpublished data