辛伐他汀对慢性心力衰竭兔心室重构、心功能影响及其作用机制.pdf

辛伐他汀对慢性心力衰竭兔心室重构、心功能的影响及其作用机制 英文摘要 withCHF rabbitsreceivedandlatetreatmentof rabbits，in Results：Compared early heart ventricular radiowere simvastatin，the weight，left weight，heartweight／bodyweight were significantlyless(p0．05-0．01，respectively)，TheIVSd，LVIDssignificantly EFandFSwere decreased①0．05—0．01，respectively)，thesignificantlyhigher(pO．05- less LVEDP apoptoticindex(AP)Wassignificantly00．01)，The 0．01，respectively)，The were sizedecreased．Intreatment significantlylower(p0．05)，cardiomyocyteearly group， leftventricular andLVPWdwere lessthan radio，LVIDd weight／bodyweight significantly CHFrabbitsalso 00．05-0．01，respectively)． Inrabbits ofRhoAin treated bysimvastatin，the expression cardiomyocytes membraneand B1 in were cyelin cardiomyocytescytosolsignificantlydecreased(p0．01， diminishedthe ofRho respectively)．Simvastatinsignificantly activity GTPase(pO．01， the mRNAand respectively)．SimvastatinsignificantlypromotedPPAR7 proteinexpression and ofNF—r,B (p0．0 were inhibited 1，respectively)．Theexpressionactivity sinificantly inrabbitstreated bysimvastatin(p0．01，respectively)．Simvastatinsignificantlypromoted the of in