尿白蛋白_肌酐比值检测法在早期2型糖尿病肾病中的应用.pdf

46 重庆医学2005 年1 月第34 卷第1 期 ·　　· /2 邓晓初 (重庆市第八人民医院　400015) 　　　:　探讨在门诊 2 型糖尿病(DM )患者中用晨尿查尿白蛋白/肌酐 值(ACR)方法诊断早期2 型糖尿病肾病 (T DM-DN)的可行性及对其进行干预治疗的效果。　将3 个月内尿检2 次以上的患者148 例按尿白蛋白排出量分为两组: 2 微量白蛋白尿组(MA 组)和正常白蛋白尿组(NA 组), 对MA 组患者给予干预治疗, 较两组临床特点及观察MA 组治疗效果。 　微量白蛋白尿(MA)检出率48.7%, DM 病程和高血压病程与MA 的发生率呈正相关, MA 组治疗6 ～30 (13.4 ±6.9)个月 前后 较,尿白蛋白排出量减少显著。 　在门诊 DM 患者中采用 ACR 法作为常规筛查和监测 MA 简便易行, 有利于对 T DM 患者肾脏和血管并发症的防治。 2 :2 型糖尿病;微量白蛋白尿;治疗 :R587.1;R446.122 :A :167 1-8348(2005)01-0046-03 Clinical study on applying urinary albumin/creatinine values test to diagnose and treat early diabetic nephropathy in type 2 diabetes D EN G X iao-chu (Department of Endocrinolo y, Chon qin Ei hth Peoples Hospital, Chon qin 400015, China) Abstract :Objective　To investi ate the feasibility of applyin urinary albumin to creatinine ratio (ACR)test on the first-mornin urine sample to dia nose early diabetic nephropathy (DN)in outpatient w ith type 2 diabetes mellitus (T DM ), and to analyse the effect 2 of intervention for these subjects.Methods　ACR w as performed to screen microalbuminuria (MA).One hundred and fourty-ei ht sub- jects w ho were measured by at least two separate urine specimens in 3-month w ere divided into tw o roups:microalbuminuria roup (MA roup)and normoalbuminuria roup (NA roup).Intervention was iven by follow in these patients w ith MA.The clinical characteris- tics of two roups were compared and the intervenient effect was studied in MA roup.Results　The prevalence of MA w as 48.7%that revealed a si nificant positive correlation with duration of diabetes and/or hypertens