高脂血症性急性胰腺炎的发病机制及诊疗进展要点讲解.doc

ISSN 1009-3079 CN 14-1260/R?世界华人消化杂志?2008年2月28日;16(4): 343-349 高脂血症性急性胰腺炎的发病机制及诊疗进展?孙诚谊, 潘耀振 孙诚谊, 潘耀振,?贵阳医学院附属医院肝胆外科 贵州省贵阳市 550001孙诚谊, 教授, 主要从事肝胆胰脾基础与临床.作者贡献分布:?此课题由孙诚谊设计, 并由孙诚谊, 潘耀振共同收集资料及数据分析, 本论文写作由孙诚谊, 潘耀振完成.通讯作者:?孙诚谊, 550001, 贵州省贵阳市贵医街28号, 贵阳医学院附属医院肝胆外科. chengyisun@电话: 0851-6773083收稿日期: 2007-05-14 修回日期: 2008-01-05Advances in pathogenesis of hyperlipidemic acute pancreatitis and its diagnosis and treatment?Cheng-Yi Sun, Yao-Zhen Pan?Cheng-Yi Sun, Yao-Zhen Pan,?Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang 550001, Guizhou Province, ChinaCorrespondence to:?Cheng-Yi Sun, Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, 28 Guiyi Street, Guiyang 550001, Guizhou Province, China. chengyisun@Received:?2007-05-14?Revised:?2008-01-05?AbstractHyperlipidemia is one of the causes for acute pancreatitis. Hyperlipidemic acute pancreatitis often occurs in patients with type Ⅰ, Ⅴ or Ⅳ hyperlipidemia. It results from chemical irritation to the pancreas and disturbance of pancreatic microcirculation due to the toxicity of free fatty acids released from massive triglycerides. When the serum triglyceride level is elevated, the incidence of complications may increase accordingly. However, serum amylase levels may be normal in serum of some patients or lightly e1evated. The diagnosis of hyperlipidemic acute pancreatitis is mainly based on the clinical manifestations of acute pancreatitis and the serum triglyceride level. Therefore, hyperlipidemic acute pancreatitis patients are treated mainly by reducing their serum triglyceride level.?Key Words:?Acute pancreatitis; Hyperlipidemia; Triglyceride; Diagnosis; TreatmentSun CY, Pan YZ. Advances in pathogenesis of hyperlipidemic acute pancreatitis and its diagnosis and treatment. Shijie Huaren Xiaohua Zazhi 2008; 16(4): 343-349摘要高脂血症(HL)是急性胰腺炎(AP)的病因之一. 高脂血症性急性胰腺炎通常见于Ⅰ型、Ⅴ型或Ⅳ型HL患者. 而其发病机制主要是由于高水平甘油三酯(TG)分解的游离脂肪酸(FFA)对胰腺本身的毒性作用及其引起