the impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment规定的影响,安全注意事项和物理限制在最大biocontainment研究进展.pdf

Viruses 2012, 4, 3932-3951; doi:10.3390/v4 123932 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Impact of Regulations, Safety Considerations and Physical Limitations on Research Progress at Maximum Biocontainment 1 1 2 3 Amy C. Shurtleff , Nicole Garza , Matthew Lackemeyer , Ricardo Carrion, Jr. , Anthony Griffiths 3, Jean Patterson 3, Samuel S. Edwin 4 and Sina Bavari 1,* 1 Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA; E-Mails: amy.c.shurtleff.ctr@ (A.C.S.); nicole.garza@ (N.G.) 2 Integrated Research Facility Frederick, Division of Clinical Research, National Institute of Allergy and Immunology, National Institute of Health, Frederick, MD 21702, USA; E-Mail: matthew.lackemeyer@ 3 Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, USA; E-Mails: carrion@ (R.C.); agriffiths@ (A.G.); jpatters@ (J.P.) 4 Select Agent Management Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA; E-Mail: samuel.edwin@ * Author to whom correspondence should be addressed; E-Mail: sina.bavari@; Tel.: +1-301-619-4246; Fax: +1-301-619-0350. Received: 22 November 2012; in revised form: 14 December 2012 / Accepted: 14 December 2012 / Published: 19 December 2012 Abstract: We describe herein, limitations on resear