ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular visionten_m3调节eye-specific模式哺乳动物视觉通路和双目视觉需要.pdf

PLoS BIOLOGY Ten_m3 Regulates Eye-Specific Patterning in the Mammalian Visual Pathway and Is Required for Binocular Vision 1,2* 1 1 1 3 1 Catherine A. Leamey , Sam Merlin , Paul Lattouf , Atomu Sawatari , Xiaohong Zhou , Natasha Demel , 1 3 2 ¨ 3 Kelly A. Glendining , Toshitaka Oohashi , Mriganka Sur , Reinhard Fassler 1 Department of Physiology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, Australia, 2 Brain and Cognitive Sciences and Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Molecular Medicine, Max-Planck Institute for Biochemistry, Martinsried, Germany Binocular vision requires an exquisite matching of projections from each eye to form a cohesive representation of the visual world. Eye-specific inputs are anatomically segregated, but in register in the visual thalamus, and overlap within the binocular region of primary visual cortex. Here, we show that the transmembrane protein Ten_m3 regulates the alignment of ipsilateral and contralateral projections. It is expressed in a gradient in the developing visual pathway, which is consistently highest in regions that represent dorsal visual field. Mice that lack Ten_m3 show profound abnormalities in mapping of ipsilateral, but not contralateral, projections, and exhibit pronounced deficits when performing visually mediated behavioural tasks. It is likely that the functional deficits arise from the interocular mismatch, because they