antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions抗高血压药物胍那苄活跃体内酵母和哺乳动物朊病毒.pdf

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions ´ 1,2,3,4,5 ´ 6 5 7 ´ Deborah Tribouillard-Tanvier , Vincent Beringue , Nathalie Desban , Fabienne Gug , Stephane 5 ´ 1,2,3,4 ´ 7 6 6¤ 1,2,3,4 Bach , Cecile Voisset , Herve Galons , Hubert Laude , Didier Vilette , Marc Blondel * ´ ´ ´ 1 INSERM U613, Brest, France, 2 Univ Brest, Faculte de Medecine et des Sciences de la Sante, UMR-S613, Brest, France, 3 Etablissement Franc¸ais du Sang (EFS) Bretagne, ´ ´ ´ Brest, France, 4 CHU Brest, Hop Morvan, Laboratoire de Genetique Moleculaire, Brest, France, 5 CNRS UPS2682, Station Biologique, Protein Phosphorylation and Disease ´ Laboratory, Place Georges Teissier, Roscoff, France, 6 Institut National de la Recherche Agronomique (INRA), UR892, Virologie Immunologie Moleculaires, Jouy-en-Josas, ´ France, 7 INSERM U648, Laboratoire de Chimie Organique 2, Universite Paris Descartes, Paris, France Abstract Background: Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. Methodology/Principal Findings: Here we report the discovery of the in vivo antiprion activity of Guanabenz