体外模拟心肌环境诱导骨髓间充质干细胞向心肌细胞的分化.pdf

中国组织工程研究与临床康复彳事J2誊彳享8期2008—02—19出版 Journal RehabilitativeTissue Research ofClinical EngineeringFebruary19,2008VoLl2，No．8 疋7易疋基冽 体外模拟心肌环境诱导骨髓间充质干细胞向心肌细胞的分化★ 屈佳，高东来 Ii●●■●●●■●●■■●●■■■●●●●■●■■■■■●●■■■■●■■■●■■■■■■●■■■■■●■■■■■■●●■■■●■■●■■●■●●■■●●■■■■●—■■■■■■■■■■■●●■■●■■●■■■■●●●■■■■●■■■■■■■■■■●●■■■■●■■■■■■●●■■■■■●■■一 Differentiationof marrow cardiac bone stemcellsinto mesenchymal cardiomyocytesbysimulating microenvironmentinvitro QuJia，Gao Dong-lai Abstract AlM：Informerstudies．semipermeablemembranecoatedwith islaidinculturedishwithboneina．iTOW Grade2005ofShahxi cardiomyocytes mesenchymal Medical stem BMSCsareculturedinmediaculturedwith in isfound． University, cells(BMSCs)．or cardiomyocytes．Nospecificproteincardiomyocytes on Talyuan030001， The simulatedthecardiacmicroenvironmentinvitrotoobservetIleeffectsofcardiacmicroenvironmentthedifferenfiationof study Shami Province． BMSCsinto lheinducfiveeffectwitIlinductor cardiomyocytes．andcompare 5-aT．acytidinef5．aza)． China were attheCenter ofShanxjMedical fromMarchto Ⅳ叮HODS：Experimentsperformed Laboratory UIlivcrsity September2007．(D WistarratsandtenWistarmtsagedl were AnimalRoomofShanxiMedical