studies of the association of arg72pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 europeans研究协会的arg72pro肿瘤抑制蛋白p53与2型糖尿病合并分析55521年的欧洲人.pdf

Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans 1,2 1 1 1 Kristoffer Sølvsten Burgdorf *, Niels Grarup , Johanne Marie Justesen , Marie Neergaard Harder , 3 4,5 6 6 2,5 Daniel Rinse Witte , Torben Jørgensen , Annelli Sandbæk , Torsten Lauritzen , Sten Madsbad , 1,7 1,5,8 Torben Hansen , DIAGRAM Consortium , Oluf Pedersen 1 Hagedorn Research Institute, Copenhagen, Denmark, 2 Hvidovre Hospital, Copenhagen, Denmark, 3 Steno Diabetes Center, Copenhagen, Denmark, 4 Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark, 5 Faculty of Health Sciences, Institute of Biomedical Science, University of Copenhagen, Copenhagen, Denmark, 6 Department of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark, 7 Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, 8 Faculty of Health Science, University of Aarhus, Aarhus, Denmark Abstract Aims: A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-