_肺癌患者外周血T淋巴细胞亚群变化特点和临床意义.pdf

# 10 16 # 20 10 26 doi : 10. 3969/ j. issn. 1000- 484X. 2010 . 11. 012 ## T ¹ º » » ( 上海交通大学医学院附属仁济医院呼吸科, 上海200127) R734 A 1000-484X(2010)11-1016-05 [ ] : T : 56 ( 20 36 ) 18 ( Peripheral blood mononuclear cells, PBMC) T ( CD3+ ) Th ( CD3+ CD4+ ) Tc ( CD3+ CD8+ ) NKT ( CD3+ CD16+ CD56+ ) NK ( CD3- CD 16+ CD56+ ) T ( Treg , CD4+ CD25+ Foxp3+ ) CD4+ T CD3+ CDT : 56 T ( CD3+ ) ( 61. 41% ? 7. 88% vs 71. 63% ? 5. 59% , P 0. 001) , Tc ( 23 . 58% ? 7. 18% vs 28 . 44% ? 5120% , P 0105) , Treg ( 6 . 20% ? 1. 63% vs 3. 65% ? 2. 00% , P 0. 001) CD3+ CDT ( 3. 35 % ? 1. 41% vs 5 . 53% ? 1. 87% , P 0 . 01) CD3+ CDT ( 3. 70% ? 1. 89 % vs 2. 64 % ? 1. 41% , P 0 . 05) , Treg ( 6. 78% ? 2. 64% vs 5 . 06 % ? 1. 22% , P 0. 05) NK ( 15. 02% ? 7. 61% vs 18 . 74 % ? 6 . 39% , P 0 . 05) , Th NKT , ( P 0. 05) : T Th Tc NK , Treg , Treg CD3+ CDT [ ] T T CDT The clinical significance of T lymphocyte s bsets in peripheral blood from patients with l ng carcinoma ZOU Jing , LI U Bin, CHEN Xue-H ua, LI Ning-L i, WANG L i. Dep artment o Pulmonary , Renj i H osp ital, Shanghai Jiao- Tong University School o Medicine, Shanghai 200127, China [Abstract] Objective:To investigate T lymphocyte subsets in peripheral blood from patient s w ith lung carcinoma, and it s clinical signif- icance. Methods:The lymphocyte subset s in peripheral blood from 56 lung cancer patients and 18 healthy controls were measured via direct im- munofluorescent assay by flow cytometry. The lymphocyte