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乳腺浸润性导管癌超声特征与分子生物标志物的相关性(基础医学范文).doc

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乳腺浸润性导管癌超声特征与分子生物标志物的相关性(基础医学范文) 文档信息 属性: F-00P70V,doc格式,正文6597字。质优实惠,欢迎下载! 适用: 作为文章写作的参考文献,解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 作者: 佚名 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 搞要 1 关键字:乳腺浸润性导管癌;超声表现;雌激素受体;孕激素受体 2 2 结果 5 3 讨论 5 [参考文献] 7 论文原创声明(模板) 9 论文致谢(模板) 9 正文 乳腺浸润性导管癌超声特征与分子生物标志物的相关性(基础医学范文) 搞要 摘要:目的探讨乳腺浸润性导管癌的超声特征和分子生物标志物表达之间的关系。方法回顾性方便收集2014年2月―2017年2月该院收治的134例经手术病理确诊为乳腺浸润性导管癌患者的术前超声影像学资料,包括肿块最大直径、边缘毛刺、纵横比、微钙化、血流分级、腋窝淋巴结转移,并采用免疫组化方法检测ER、PR、HER-2、Ki-67及E-cad的表达情况,研究分析两者的相关性。结果ER、PR、HER-2、Ki-67和E-cad的表达阳性率分别为%、%、%、%和%。肿块最大直径2cm组Ki-67表达阳性率明显高于肿块最大直径≤2cm组(P);边缘毛刺征者ER、PR表达阳性率明显高于无边缘毛刺征者(P);有微钙化者HER-2表达阳性率明显高于无微钙化者(P);无淋巴结转移者E-Cad表达阳性率高于有淋巴结转移者(P)。结论乳腺IDC的部分恶性超声表现与病理生物学分子表达之间有一定的相关性,可尝试从超声角度评估乳腺癌分子表达情况,对乳腺癌的个体化诊治及预后评估具有重要参考价值 关键字:乳腺浸润性导管癌;超声表现;雌激素受体;孕激素受体 [中图分类?] R737 [文献标识码] A [文章编号] 1674-0742(2017)10(b)-0020-04 [Abstract] Objective This paper tries to explore the correlation of ultrasonographic features and biomarkers in invasive breast ductal carcinoma. Methods Preoperative ultrasound imaging data of 134 cases of surgical pathology confirmed breast invasive ductal carcinoma patients treated in this hospital from February 2014 to February 2017 were retrospectively collected, including the maximum diameter of the tumor, edge burr, aspect ratio, microcalcification, blood flow grade, axillary lymph node metastasis. The correlation between ER, PR, HER-2, Ki-67 and E-cad was detected by immunohistochemistry. Results The positive rate of ER, PR, HER-2, Ki67 and E-cad were %, %, %, %, % respectively. The positive rate of Ki-67 in tumor size2 cm was statistically significantly higher than that of tumor size≤2 cm group (P). The positive rates of ER, PR in spicule sign group were statistically significantly higher than that group without spicule sign (P). The positive rate of HER-2 in microcalcification group was statistically significantly higher than that group without microcalcification (P). The positive rate of E-Cad in metastasis to lymph node group was
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