三阴乳腺癌临床病理特征与分子标志物的相关性.PDF

临床与病理杂志 2017, 37(2) 408 J Clin Path ol R e s doi: 10.3978/j.issn.2095-6959.2017.02.031 View this article at: /10.3978/j.issn.2095-6959.2017.02.031 三阴乳腺癌临床病理特征与分子标志物的相关性 1,2 2 2 2 王晶晶 ，张旭辉 综述 冯晓燕 ，房涛 审校 (军事医学科学院 1. 附属医院病理科，北京 100071；2. 基础医学研究所，北京 100850) [摘　要] 三阴乳腺癌 (triple-negative breast cancer ，TNBC) 即雌激素受体(estrogen receptor ，ER) 、孕激素受 体 (progestogen receptor ，PR) 、人表皮生长因子受体-2(human epithelial growth factor receptor-2 ， HER-2) 均为阴性的乳腺癌。对内分泌治疗和抗 HER-2 的治疗无效，其分子亚型较多，存在基因 表达差异，异质性明显，缺乏有效的分子靶标，且具有较高的侵袭转移率及复发率、预后差，临 床病理学特征独特，因此探寻TNBC 的临床病理特征及其分子标志物，对临床进一步诊断及治疗 TNBC具有重要意义。 [关键词] 三阴乳腺癌；临床病理特征；分子标志物 Correlation between clinicopathological features of triple- negative breast cancer and molecular markers 1,2 2 2 2 WANG Jingjing , ZHANG Xuhui , FENG Xiaoyan , FANG Tao (1. Department of Pathology, The Affiliated Hospital of Military Medical Sciences, Beijing 100071; 2. Department of Bio-diagnosis, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China) Abstract Triple-negative breast cancer (TNBC) is characterized by a lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) expressions. TNBC is invalid for endocrine therapy and anti-HER-2 therapy. TNBC is a heterogeneous breast cancer group and lacks of effec