susceptibility of primary htlv-1 isolates from patients with htlv-1-associated myelopathy to reverse transcriptase inhibitors患者易感性初级htlv 1分离htlv-1-associated脊髓病逆转录酶抑制剂.pdf

Viruses 2011, 3, 469-483; doi:10.3390/v3050469 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Susceptibility of Primary HTLV-1 Isolates from Patients with HTLV-1-Associated Myelopathy to Reverse Transcriptase Inhibitors Beatrice Macchi 1,5, Emanuela Balestrieri 1, Arianna Ascolani 1, Silva Hilburn 2, Fabiola Martin 3, Antonio Mastino 4,6 and Graham P Taylor 2,3,* 1 Department of Neuroscience, University of Rome “Tor Vergata”, Via Montpellier 1, 00133, Rome, Italy; E-Mails: macchi@med.uniroma2.it (B.M.); balestrieri@med.uniroma.it (E.B.); ascolaria@libero.it (A.A.) 2 Department of Communicable Diseases, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK; E-Mail: s.hilburn@imperial.ac.uk (S.H.) 3 National Centre for Human Retrovirology, St. Mary’s Hospital, Imperial College Healthcare NHS Trust, Praed St, London W2 1NY, UK; E-Mail: fabiola.martin@hyms.ac.uk (F.M.) 4 Department of Life Sciences, Section of Microbiological, Genetic and Molecular Sciences, University of Messina, Via F. Stagno d’Alcontres 31, 98166, Messina, Italy; E-Mail: antonio.mastino@unime.it (A.M.) 5 IRCCS, Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy 6 IRCCS Centro Neurolesi “Bonino- Pulejo”, Via Provinciale Palermo, 98124 Messina, Italy * Author to whom correspondence should be addressed; E-Mail: g.p.taylor@imperial.ac.uk; Tel.: +44-207-594-3910; Fax: +44-207-594-3910. Received: 25 February 2011; in revised form: 6 April 2011 / Accepted: 21 April 2011 / Published: 5 May 2011 Abstract: Since human T-lymphotropic virus type 1