autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children自闭症相关基因表达之间的外周白细胞通常观察到科目自闭症和自闭症儿童健康女性.pdf

Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children 1 2 1 1 2 3 Yuki Kuwano *, Yoko Kamio , Tomoko Kawai , Sakurako Katsuura , Naoko Inada , Akiko Takaki , Kazuhito Rokutan1 1 Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan, 2 Department of Child and Adolescent Mental Health, National Institute of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan, 3 Chichibu-Gakuen Institution and Clinic for Intellectually Disabled Children, National Rehabilitation Center for Persons with Disabilities, Saitama, Japan Abstract Autism spectrum disorder (ASD) is a severe neuropsychiatric disorder which has complex pathobiology with profound influences of genetic factors in its development. Although the numerous autism susceptible genes were identified, the etiology of autism is not fully explained. Using DNA microarray, we examined gene expression profiling in peripheral blood from 21 individuals in each of the four groups; young adults with ASD, age- and gender-matched healthy subjects (ASD control), healthy mothers having children with ASD (asdMO), and asdMO control. There was no blood relationship between ASD and asdMO. Comparing the ASD group with control, 19 genes were found to be significantly changed. These genes were mainly involved in cell morphology, cellular assembly and organization, and nerve system development and function. In addition, the asdMO group possessed a unique gene expression signature shown as significant alterations of protein synthesis despite of their nonautistic diagnostic status. Moreover