吲哚胺2_3二氧化酶在造血干细胞移植研究进展.pdf

362 Chin J Obstet Gynecol Pediatr ( Electron Ed) , A g st 2011, Vol. 7, No. 4 2, 3 叶启翔 方建培 2, 3 ( indoleamine 2, 3dioxygenase, IDO) , ( dendritic cells, DCs) T ( hemat opoietic st em cell transplantation, HSCT) T , ( graft vers s host disease, GVHD) 2, 3 2, 3 ; ; ; ResearchProgress of Indoleamine 2, 3Dioxygenase on Hematopoietic Stem Cell Transplantation YE Qi xiang, FA NG Jianp ei. Dep artment of Pediatrics, Sun YatSen Memorial osp ital of Sun YatSen University , Guangz hou 510120, Guangdong Prov ince, China. ( Corresp onding author: FA NG Jianp ei, Email: j pf ang2005 @163.com) Abstract Indoleamine 2, 3dioxygenase ( IDO) is fo nd co ld ind ce T cells imm nity tolerance by ind cing tryptophan decompose, reg lating dendrit ic cells and T cells and relevant molec lar mechanism to prevent graft vers s host disease( GVHD) and improve the s rvive rate of graft. It has became a therape tic target to improve the s ccess rate of hematopoietic stem cell t ransplantat ion( H SCT ) . ey words indoleamine 2, 3dioxygenase ( IDO ) ; hematopoietic stem cell t ransplantat ion ( H SCT ) ; imm nity tolerance; graft vers s host disease( GVH D) * Project No . s pported by the National Nat ral Science Fo ndation of China; project No. 20090171110064, s pported by the Doctor Degree Fo ndat ion of Technology Ministry of China. 2, 3 ( indoleamine 2, 3 cells, DCs) DCs IDO dioxygenase, IDO) , , ( interferon, [ 6~ 8] , IFN) [ 1, 2] , 2 2,3 T , [ 3~ 5] T , IDO 2. 1 2, 3 IDO ( hematopoietic stem HSCT cell transplantation, H SCT ) , , ,