造血干细胞分化相关基因的研究进展64585.pdf

110 2002 2 23 2 Chin J Hematol, ebruary 2002, Vol 23, No. 2 王立 陈赛娟 ( hematopoietic stem cell, HSC) Hlx HoxB7, , Hlx , , , HoxB7 HL-60 1. 2 GATA : GATA [4] , GATA- 1 GATA-2GATA-3GATA-4 X, 3, 10, 8 , , T (T- X, 6, 2, 14 cell acute lymphocyticstem cell leukemia, TAL1SCL) GATA-2 ( globin) GATA- 1 A Hox(homeobox) B4IK2c-mplDLk(delta-like) , TGATAAG, GATA- 1 , , GATA- 1, GATA- 1 [1] : GATA- 1 , GATA-2 , [ 2] , GATA-2 , GATA-2 GATA-2 1 , , 1. 1 Hox : Hox(homeobox) HTH DNA GATA-2 [5] ( homeo ) , Hox , GATA-2 , GATA-3 T Hox 61 , DNA GATA-4 , 38Hox , 8~ 11 1. 3 CEBP : CEBP( CCAAT) bZIP HoxAHoxBHoxCHoxD 7 17 , 5 : CEBPCEBPCEBP 12 4 , 8 11 15 CEBPCEBP CEBPCEBP 19 , 2 38 Hox 356 , , HoxB4, 5, 6, 7 HoxC10, 11, 12, 13 , CD34 + CD33 + CEBP, HoxA9, 10, 11, 12 HoxC5, 6, 8, 9 4 CD34+ CD33 + , 32DC13 G-CS HoxD HoxB3 , CEBP, CEBP [ 3] HoxB4 Sauvageau , CEBPCEBP HoxB4 20 , 344 , CEBP -HoxB4 , B , , HoxA9, 10 CD34 + CEBP(ubiquitous) , 19