生姜降血糖及抗糖尿病性白内障作用.pdf

Molecular Vision 2010; 16:1525-1537 /molvis/v16/a165 © 2010 Molecular Vision Received 10 May 2010 | Accepted 3 August 2010 | Published 10 August 2010 Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats 1 1 1 1 Megha Saraswat, Palla Suryanarayana, Paduru Yadagiri Reddy, Madhoosudan A. Patil, 2 1 Nagalla Balakrishna, Geereddy Bhanuprakash Reddy 1 2 Biochemistry Division, National Institute of Nutrition, Hyderabad, India; Statistics Division, National Institute of Nutrition, Hyderabad, India Purpose: Advanced glycation end products (AGE) are associated in the development of several pathophysiologies including diabetic cataract. Earlier we have reported that some common dietary agents have antiglycating activity and ginger (Zingiber officinalis) was one of the few prominent agents that effectively prevented AGE formation in vitro. In this study we investigated the potential of ginger to prevent diabetic cataract in rats. Methods: Diabetes was induced in Wistar-NIN rats by intraperitoneal injection of streptozotocin (35 mg/kg bodyweight) and the control rats received vehicle alone. While a set of diabetic animals received AIN-93 diet, another set received either 0.5 or 3% ginger in their diet for a period of two months. Cataract progression was monitored by slit-lamp biomicroscope. At the end of two months, the animals were sacrificed to evaluate non-enzymatic glycation and osmotic stress in the eye lens.