Combretastatin A4 phosphate溶液光解动力学研究.pdf

c ombretastati n “phosphate 溶液光解动jJ 学研究 莫毅，贺英菊 ‘，闰根全，林丽洋，陈艳( 四川大学华西药学院，成都61400 )1 摘要: 目的 考察oC mb，tas ttia n A4 pho Ps hta e( CA4 P) 溶液的光解机制及光解动力学规律。方法 在不同光源下对CA4 P 溶液 进行加速实验，HPLC 测定含量。结果 不同浓度溶液在相 同光源下的光解动力学有显著差异，在不同的光源下相同浓度溶 液的光解动力学也有显著差异。在汞灯下，随pH 增大，CA4 P 溶液光解速率变大;在 日光灯下，随pH 增大，CA4 P 溶液光解速 率变小。CA4 P 水溶液的光解速率常数(k =0.oo 7 h一’) 小于cA4 P 甲醇溶液的光解速率常数(k 二0.005 8 h一’) 。刀一cD、HP- 户CD、wTe en 80对CA4 p 溶液的光解速率常数影响:kbl。。k(l xlo一6L ·mol一’·h一’) kHP，一cD(7xlo一7L ·mol一’·h一)‘=k、。e。:。 (7xlo一，L ·mol一’·h一’) ke- cD(6xlo一7L ·mol一’·h一’) 。结论 光源、浓度、pH、溶#Jl 对C解P溶液的光解过程有显著影 响尹一CD、HP尹一CD ，wT ee n 08 对CA4 P 溶液的光解过程有一定抑制作用。 关键词:Combre tastatin A4 phosphate ;光解; 包合物 中图分类号:R9 96 . 1 文献标识码:A 文章编号: 100 1一494( oo )7 07 一0516 一40 on Ph oto lysis 儿ne tics of Combr eta sta ti n A4 PhosPh ate Solution M 0 Yi ，HE Ying一u ‘，YAN Gen一quan ，LI N Li一yang ，CHEN Yan( 肠 以‘ina cs hool of hP arnz a盯，Sichuan 流二rs i妙，hC e咭- d u 6 1004 1 ，hC ina ) ABSTRACT :OBJECTIVE To study photo lysis kinetics Of combretastta in A4 phosphate solution. METHODS CA4 P solution was exposed to dieff re nt light. Samples were determ ined by HPLC. RE SULTS The photolysis kinetics of CA4 P solution at dieff re nt con- centrta ion under the sma e lihg t was dieff rent. The photolysis kinetics of CA4 P solution at the same concentra tion under dieff rent light was dieff re nt. Under merc u叮lma p ，photolysis rate was increased with pH increase ;under daylight lamp ，photo lysis rta e was decre ased wiht pH incre as e hT e photolysis ra te constant 。f c解p in wta er was smaller thna that in methanol ，re spectively ( 人= 0. oo 7 h 一’ and k=0.oo5 8 h一’) .hT e eeff ct of月一cD，HP尹一cn ，物een 8o on the photolysis rate constant of CA4 p wa s dieff rent ，the sequence was as of llows:k。，k(l x lo一6L ·m