文档详情

synthesis of new n-arylpyrimidin-2-amine derivatives using a palladium catalyst使用钯催化剂合成的新n-arylpyrimidin-2-amine衍生品.pdf

发布：2017-09-08约5.71万字共13页下载文档

文本预览下载声明

Molecules 2008, 13, 818-830 molecules ISSN 1420-3049 © 2008 by MDPI /molecules Full Paper Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst Ibrahim Mustafa El-Deeb 1, Jae Chun Ryu 2 and So Ha Lee 1,2,* 1 Department of Biomolecular Science, University of Science and Technology, Daejon, Korea; E-mail: dr_i_eldeeb_2003@ 2 Life Sciences Research Division, Korea Institute of Science Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea; E-mail: ryujc@kist.re.kr * Author to whom correspondence should be addressed; E-mail: LSH6211@kist.re.kr; Tel: (+82) 2 9586834. Received: 26 March 2008; in revised form: 8 April 2008 / Accepted: 8 April 2008 / Published: 9 April 2008 Abstract: New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tert- butoxide in refluxing toluene under a nitrogen atmosphere. The target N-aryl derivatives were obtained in moderate to good yields ranging from 27% to 82%. The procedure described could be widely employed for the preparation of new heterocyclic compounds. The structures of the new compounds were confirmed by FT-NMR, FT-IR and elemental analysis. Keywords: Palladium catalyst, N-arylation, aminopyrimidine, xantphos, Suzuki coupling, Buchwald-Hartwig amination. Introduction The 2-aminopyrimidine moiety is a common stru

显示全部

相似文档

synthesis of some oxadiazole derivatives as new anticandidal agents合成一些oxadiazole衍生品新anticandidal代理.pdf Molecules 2011, 16, 7662-7671; doi:10.3390/molecule OPEN ACCESS
2017-09-09 约3.79万字 10页立即下载
synthesis of new pyrazole and pyrimidine steroidal derivatives新吡唑并嘧啶的合成甾族的衍生品.pdf Molecules 2003, 8, 444-452 molecules ISSN 1420-3049
2017-09-09 约2.93万字 9页立即下载
synthesis of new racemic α,α-diaminocarboxylic ester derivatives的新合成外消旋α,α-diaminocarboxylic酯衍生品.pdf Molecules 2010, 13, 9354-9363; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-10 约4.32万字 10页立即下载
synthesis, characterization and cytotoxicity of new rotundic acid derivatives合成、表征和细胞毒性的新rotundic酸衍生品.pdf Molecules 2012, 17, 1278-1291; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-11 约6.54万字 14页立即下载
synthesis and antimicrobial activity of some new 1,3,4-thiadiazole derivatives合成及抗菌活性的一些新的1,3,4-thiadiazole衍生品.pdf Molecules 2012, 17, 14625-14636; doi:10.3390/molecules171214625 OPEN ACCESS molecules
2017-09-08 约5.19万字 12页立即下载
synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives合成和新8-nitrofluoroquinolone衍生品的抗菌性能.pdf Molecules 2007, 12, 1240-1258 molecules ISSN 1420-3049
2017-09-10 约7.94万字 19页立即下载
synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives合成及抗菌活性的一些新1、2,4-triazole衍生品.pdf Molecules 2010, 15, 2427-2438; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-08 约6.22万字 12页立即下载
synthesis and reactivity of new 1-pentafluorophenyl-1hpyrrole derivatives合成和反应性的新1-pentafluorophenyl-1hpyrrole衍生品.pdf Molecules 2003, 8, 536-540 molecules ISSN 1420-3049
2017-10-31 约字 5页立即下载
synthesis of some thienopyrimidine derivatives合成一些thienopyrimidine衍生品.pdf Molecules 2006, 11, 498-513 molecules ISSN 1420-3049
2017-09-09 约8.26万字 16页立即下载
synthesis of some new fluorinated hexahydroquinoline and acridinedione derivatives in trifluoroethanol合成一些新的氟hexahydroquinoline trifluoroethanol acridinedione衍生品.pdf Appl. Sci. 2012, 2, 368-374; doi:10.3390/app2020368 OPEN ACCESS applied sciences
2017-09-08 约2.03万字 7页立即下载
synthesis of some new 4,5-substituted-4h-1,2,4-triazole-3-thiol derivatives合成一些新的4,5-substituted-4h-1 2 4-triazole-3-thiol衍生品.pdf Molecules 2004, 9, 204-212 molecules ISSN 1420-3049
2017-09-10 约3.21万字 9页立即下载
synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via c-phenylglycine derivatives合成新的imidazolidin-2 4-dione并通过c-phenylglycine 2-thioxoimidazolidin-4-ones衍生品.pdf Molecules 2010, 15, 128-137; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-11 约4.45万字 10页立即下载
synthesis and antibacterial evaluation of new n-acylhydrazone derivatives from dehydroabietic acid合成和抗菌的评估新n-acylhydrazone衍生品脱氢枞酸.pdf Molecules 2012, 17, 4634-4650; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-08 约7.19万字 17页立即下载
synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives合成和生物评价的新5-fluorouracil-substituted ampelopsin衍生品.pdf Molecules 2010, 15, 2114-2123; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-08 约3.2万字 10页立即下载
synthesis and chemical characterisation of some new diheteroaryl thienothiophene derivatives合成和化学描述一些新的diheteroaryl thienothiophene衍生品.pdf Molecules 2011, 16, 7706-7714; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-11 约2.93万字 9页立即下载