the function and structure of the cerebrospinal fluid outflow system脑脊液流出系统的功能和结构.pdf

Pollay Cerebrospinal Fluid Research 2010, 7:9 CEREBROSPINAL FLUID RESEARCH /content/7/1/9 R E V I E W Open Access Review The function and structure of the cerebrospinal fluid outflow system Michael Pollay Abstract This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems are evaluated as to the dominance of one over the other in various species and degree of animal maturation. The functional capabilities of the total CSF drainage system are presented, with evidence that the duality of the system is supported by the changes in fluid outflow dynamics in human and sub-human primates in hydrocephalus. The review also reconciles the relative importance and alterations of each of the outflow systems in a variety of clinical pathological conditions. Review the arachnoid structures penetrating the lacuna of the Introduction sagittal sinus, which suggested a special function for The functional anatomy of the structures responsible for these arachnoidal projections. He also appreciated that the return of cerebrospinal fluid (CSF) to the general cir- the arachnoid granulations represented enlargement of culation is based on somewhat conflicting evidence as to the normal villi of the arachnoid [1]. Trolard confirmed their location, anatomical features, and functional capa- his