大光斑低能量Q开关Nd-YAG激光治疗黄褐斑的疗效分析.pdf

生堡麈丛科苤查2Q12生2旦箜笾鲞筮2基L￡丛!』旦!婴!!!!，￡!b型!g2Q12，y!!．堑，盥!：2 121 ·论著· 大光斑低能量Q开关Nd：YAG激光治疗 黄褐斑的疗效分析 潘虹 宋为民 陈书悦相文忠 韩长元许爱娥任军 【摘要】 目的探讨大光斑低能量Q开关Nd：YAG激光治疗黄褐斑的疗效，分析黄褐斑皮损激光治 疗前后共聚焦激光扫描显微镜(CLSM)特征。方法收集45例黄褐斑患者，使用大光斑低能量调Q开关 Nd：YAG1064 nm激光治疗，并在治疗前后对其行CLSM检查。结果45例患者，治疗结束后基本治愈 可见黄褐斑皮损处较周围正常皮损处表皮全层黑素颗粒增多，激光治疗后表皮处黑素颗粒显著减少。结 1064 论大光斑低能量调Q nm激光治疗黄褐斑疗效确切，安全性高，CLSM可用于判断激光治疗疗效。 【关键词】共聚焦激光扫描显微镜；黄褐斑；激光 Clinical of and QswitchedNd：YAGlaserinthetreatmentofmelasma efficacylarge-spotlow-energy PAN Jun． Hon91，SONGWei-min，CHENSbu-yue，XIANGWen-zhong,HANChang-yuan，XUAi—e，REN ofMedical of *DepartmentCosmetolo飘ThirdHospitalWuhan，W，Uhan430060，∞ina Toevaluatetheeffectof and switchedNd：YAGlaseron 【Abstract】0bjective low—energyQ large—spot toobservethe ofmelasmalesionswithconfocallaser melasma。and changes scanningmicroscopy(CLSM) beforeandafterthelasertreatment．Methods from24to48 and Totally．45patientsaged years diagnosed withfacialmelasmawereincludedinthis treatedwith and OswitchedNd： study，and large—spotlOW—energy YAGonceaweekfor10ormoresessions．CLSMwasusedtoestimatethemelanincontentinmelasmalesions beforeeachirradiationandafterthelastirradiation．Resultsthe45 Among patients．8(17．78％)werenearly afterthe cured，25(55．56％)markedlyimproved，11(24．44％)improved，andonly1(2．22％)unimproved laserirradiation．Thetotal ratewas73．33％．AsCkSMshowed．therewasaninerementinmelanin response inmelasmalesions withthenormalskin melasmalesions．butareductionin granules compared