t-cell mediated immune responses induced in ret transgenic mouse model of malignant melanomat细胞介导免疫反应诱导恶性黑色素瘤的ret转基因小鼠模型.pdf

Cancers 2012, 4, 490-503; doi:10.3390/cancers4020490 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma Oliver Abschuetz 1,†, Wolfram Osen 2,†, Kathrin Frank 1, Masashi Kato 3, Dirk Schadendorf 4 and Viktor Umansky 1,* 1 Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim , Heidelberg 69120, Germany 2 Division of Translational Immunology, German Cancer Center, Heidelberg 69120, Germany 3 Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi 487-8501, Japan 4 Department of Dermatology, University Hospital Essen, Essen 45122, Germany † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: v.umansky@dkfz.de; Tel.: +49-621-383-3773; Fax: +49-621-383-2163. Received: 27 February 2012; in revised form: 4 April 2012 / Accepted: 18 April 2012 / Published: 26 April 2012 Abstract: Poor response of human malignant melanoma to currently available treatments requires a development of innovative therapeutic strategies. Their evaluation should be based on animal models that resemble human melanoma with respect to genetics, histopathology and clinical features. Here we used a transgenic mouse model