the c-terminus of h-ras as a target for the covalent binding of reactive compounds modulating ras-dependent pathways糖基的h作为活性化合物的共价结合的目标调制ras-dependent通路.pdf

The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras- Dependent Pathways 1. ´ 1. 1 ´ 1 2 Clara L. Oeste , Beatriz Dıez-Dacal , Francesca Bray , Mario Garcıa de Lacoba , Beatriz G. de la Torre , 2 ´ 3 ´ 3 ´ ´ 4 David Andreu , Antonio J. Ruiz-Sanchez , Ezequiel Perez-Inestrosa , Carlota A. Garcıa-Domınguez , ´ 4 ´ 1 Jose M. Rojas , Dolores Perez-Sala * ´ ´ 1 Department of Chemical and Physical Biology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientıficas, Madrid, Spain, 2 Department of ´ ´ Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain, 3 Department of Organic Chemistry, Faculty of Sciences, University of Malaga, Malaga, ´ ´ ´ ´ Spain, 4 Unidad de Biologıa Celular, Area de Biologıa Celular y del Desarrollo, Centro Nacional de Microbiologıa, Instituto de Salud Carlos III, Madrid, Spain Abstract Ras proteins are crucial players in differentiation and oncogenesis and